With extensive experience in developing biologics and bioconjugates, we offer a seamless service delivered by fully integrated teams, from early discovery to commercial manufacturing.
Forward-thinking and committed, we find the best solution and use the right technologies to design, develop and manufacture your products to ensure we get vital medicines to patients quickly and safely.
We are dedicated to quality excellence. We are driven to get better treatments to market, efficiently and responsibly by reducing timelines and delivering the highest quality products and services.
We are Abzena. More than a CDMO, we are a responsible and dedicated partner that takes care of your products from concept to patient.
The Bioconjugation Development Associate Principal Scientist is responsible for helping drive bioconjugation efforts in discovery and process development to support Abzena Bristol’s scientific and manufacturing operations. This includes conjugation screening, conjugation reaction optimization, downstream purification development and scale-up activities; mentorship, training and potential management of direct reports; take lead on projects and client-facing meetings and updates; support sales and proposals process by providing technical and SME support including the design and costing of project activities as needed.
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Responsibilities
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Hands-on execution of chromatographic purifications (affinity, hydrophobic interaction (HIC), and ion exchange chromatography (IEX)), membrane filtrations (normal and tangential flow filtrations (TFF)), buffer and solution preparation, conjugation reaction work-up.
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Perform, develop and optimize bioanalytical characterization (HPLC, UPLC, LC-MS, SEC-MALS, colorimetric assays, etc.) of conjugate products.
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Help lead technical transfer of bioconjugation processes to Abzena’s bioconjugation manufacturing group including training, risk assessment, gap assessments and batch record writing and review according to ICH and FDA guidelines.
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Authoring and reviewing relevant documentation including laboratory notebooks, process development reports, protocols, batch records, SOPs, technical presentations.
Qualifications
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Demonstrated experience applying and optimizing state-of-the-art bioconjugation or bioorthogonal chemistry techniques to produce conjugates (ADCs, AOCs/ARCs, PDCs, DACs, etc.) at various scales (mg-gram scales)
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Thorough, hands-on experience with small-scale and preparative chromatography systems (AKTA Pilot, AKTA Ready, AKTA Explorer, etc.) for purification of biomacromolecules (antibodies, fusion proteins, carrier proteins, viruses, viral vectors, or other biologics).
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Experience with protein bioanalytical techniques (HPLC, LC-MS, CE-SDS, UV-spectrophotometry, etc.)
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Experience with large scale bioprocess equipment (pallet tanks, pumps, biowelders, biosealers, bio-rockers, single-use assemblies).
Travel between Abzena sites (Bristol PA, San Diego CA, Cambridge UK) as needed.
Physical Requirements
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Ability to climb, balance, stoop, kneel, crouch, or crawl.
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FLSA: Exempt
Abzena is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.
This policy applies to all employment practices within our organization, including hiring, recruiting, promotion, termination, layoff, recall, leave of absence, compensation, benefits, and training.